Hormonal Regulation of Oligodendrogenesis II: Implications for Myelin Repair

Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate.

The formation of oligodendrocytes (oligodendrogenesis) and myelin is regulated by several neurotrophic factors. Strategies to increase the level of these trophic molecules may facilitate repair in demyelinating conditions, such as multiple sclerosis (MS). Because leukocytes are a source of neurotrophic factors, and as glatiramer acetate (GA) generates T helper 2 (Th2) lymphocytes that are not k...

Hormonal Regulation of Extinction: Implications for the Mechanisms of Gender

Hormonal regulation of whole-animal performance: Implications for selection.

One of the fundamental questions in evolutionary biology is how natural selection and sexual selection mold phenotypes, and the resulting functional capacities of those phenotypes. Strong selection within animal populations is well-documented (Endler 1986; Brodie et al. 1995; Kingsolver et al. 2001) and recent reviews point toward ‘wholeanimal performance’ as being central to understanding thes...

From DNA replication and repair to hormonal regulation

Primary ovarian insufficiency greatly influences a woman’s fertility potential and her overall health. The condition affects about 1–2 % of women and in most cases, the cause is undefined. Primary ovarian insufficiency (POI) may be caused by any process that results in dysfunction or depletion of ovarian follicles, reducing the number of oocytes within the ovary. The tendency for POI to run in ...

Myelin Repair Foundation

The Myelin Repair Foundation is pleased to present this annual review of our progress toward achieving our goal of discovering and validating effective new treatment targets for multiple sclerosis. We were extremely pleased by the rapid progress of the team both in advancing frontiers of translational scientific research and demonstrating the power of the MRF Accelerated Research CollaborationT...